Ophthalmology / Solid tumors
Mechanism of action / Target
PMC-403 is a monoclonal antibody that targets the human TIE2 that regulate the angiogenesis and vessel maturation in endothelial cells. It binds to TIE2 expressing endothelial cells and normalize VEGF-induced pathological leaky blood vessels in eyes and TME (tumor microenvironment).
PMC-403 was tested in various vessel-related diseases, such as AMD (Age-related Macular Degeneration), DR (Diabetic Retinopathy), and even solid tumors. In these models, significant vessel normalizing effects were found which suggest versatile use in a wide range of indications. PharmAbcine initiated the GLP-tox study of PMC-403 in 2Q21 and expects an IND filing for eye diseases in 3Q22.
* The nonclinical data of PMC-403 in oncology at AACR 2022
* The nonclinical data of PMC-403 in ophthalmology at ARVO 2021
* EMM / 2023 / An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone
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