Indications: Solid tumors

PMC-402 is a monoclonal antibody that targets the human Tie2 that regulated activation, proliferation, and repolarization of Tie2 expressing macrophages, resulting in T cell activation.

Mechanism of action / Target

PMC-402 binds to TIE2 expressing macrophages that activate T cells in the tumor microenvironment (TME).


An increase in T cell activity along with a shift in polarization from M2 to M1 macrophages have been identified in the in vitro study. The production of samples needed for the GLP-Toxicity study is underway for the IND filing.

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