Mechanism of action / Target
PMC-402 is a monoclonal antibody that targets the human TIE2 that regulated activation, proliferation, and repolarization of Tie2 expressing macrophages, resulting in T cell activation. It binds to TIE2 expressing macrophages that activate T cells in the tumor microenvironment (TME).
An increase in T cell activity along with a shift in polarization from M2 to M1 macrophages have been identified in the in an vitro study. PharmAbcine initiated the GLP-tox study of PMC-402 in 1Q21 and expects an IND filing in 3Q22.
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